Show HN: Mycodosing.wtf – Research‑Informed Psychedelic Dosage Calculator

3 points • ing-norante • about 2 hours ago • 1 comments

I've been frustrated by existing "magic mushroom dosage calculators": most are either visually rough, only handle cubensis, or hard-code one potency value and ignore species, tolerance, and degradation.

So I built Mycodosing.wtf – a research‑informed calculator that tries to do three things better:

Models species‑level potency using psilocybin/psilocin/baeocystin mg/g with separate profiles for truffles (and syntetics!).

Outputs dose ranges (min/median/max) instead of a single magic number, using per‑species uncertainty factors for real‑world variability.

Includes a tolerance model based on 5‑HT2A receptor downregulation (dose‑dependent exponential decay over ~14 days), plus optional weight adjustment and MAOI flag.

The species potencies are pulled and normalized from LC‑MS/MS and classic chemistry papers (e.g., Garcia‑Romeu 2021, Gotvaldová 2021, Gartz/Stríbrný), then wrapped in a neobrutalist UI built with Vite + React. 100% client-side.

I'd love feedback on:

The dose model itself (any flaws in the math or assumptions?) Species data you'd adjust or supplement What you'd want from a v2

Site: https://mycodosing.wtf/ Code: https://github.com/ing-norante/mycodosing.wtf/